Tolcapone


w89



General information:


Withdrawn ID: w89
Canonical SMILES:
Standard InChI:
Standard InChIKey:
ATC class(es): N04BX01
Molecular Formula: C14H11NO5
Molweight: 273.241



Withdrawal information:


Withdrawn due to drug safety reasons:Yes
First approved: 1998
First death: 1998
First withdrawn: 1998
Last withdrawn: 1998
Reference: https://www.ncbi.nlm.nih.gov/pubmed/21574210



Side-effects:

Total reported cases (submitted by medical professionals) with Tolcapone as primary suspect: 39


Reported final outcomes:
Hospitalization (initial or prolonged): 15
Death: 11
Disability: 1
Life-Threatening condition: 1


Reported side-effects:

Side-effect Case number
ALANINE AMINOTRANSFERASE INCREASED7
BLOOD ALKALINE PHOSPHATASE INCREASED4
ASPARTATE AMINOTRANSFERASE INCREASED4
PLEURAL EFFUSION3
PARKINSON'S DISEASE3
HEPATIC FAILURE3
HALLUCINATION3
GAMMA-GLUTAMYLTRANSFERASE INCREASED3
DRUG INEFFECTIVE3
DIARRHOEA3
BLOOD LACTATE DEHYDROGENASE INCREASED3
Urinary retention2
TRANSAMINASES INCREASED2
SUICIDAL IDEATION2
SUDDEN DEATH2
RESPIRATORY DISTRESS2
RESPIRATORY ARREST2
MULTI-ORGAN FAILURE2
METASTASES TO LIVER2
LIVER FUNCTION TEST ABNORMAL2
INTERNATIONAL NORMALISED RATIO INCREASED2
Hypotension2
HEPATIC ENZYME INCREASED2
GENERAL PHYSICAL HEALTH DETERIORATION2
FALL2
DEATH2
CONDITION AGGRAVATED2
BLOOD BILIRUBIN INCREASED2
ATRIAL FIBRILLATION2
AGITATION2
WEIGHT DECREASED1
VOMITING1
VOLVULUS1
Unresponsive to stimuli1
TRICUSPID VALVE DISEASE1
TREMOR1
THERAPY NON-RESPONDER1
SUICIDE ATTEMPT1
SMALL INTESTINE CARCINOMA1
Sinus bradycardia1
SHOCK1
SEROTONIN SYNDROME1
SEPTIC SHOCK1
RESPIRATORY FAILURE1
RENAL IMPAIRMENT1
RENAL FAILURE1
RENAL CELL CARCINOMA STAGE UNSPECIFIED1
RALES1
PYREXIA1
Pyelonephritis1
Pulmonary sepsis1
PULMONARY OEDEMA1
PULMONARY EMBOLISM1
PULMONARY CONGESTION1
PORTAL HYPERTENSION1
Pneumonia aspiration1
PNEUMONIA1
PATHOLOGICAL GAMBLING1
PANCREATIC DISORDER1
PALLOR1
OEDEMA PERIPHERAL1
NEUTROPHILIA1
NEUROLEPTIC MALIGNANT SYNDROME1
MYOCARDIAL INFARCTION1
MITRAL VALVE DISEASE1
METABOLIC ACIDOSIS1
MALIGNANT NEOPLASM PROGRESSION1
LYMPHADENOPATHY1
LUNG DISORDER1
LIVER DISORDER1
LEUKOCYTOSIS1
KLEPTOMANIA1
KETONURIA1
ISCHAEMIC STROKE1
INTENTIONAL OVERDOSE1
HYPOGLYCAEMIC COMA1
HYPOAESTHESIA1
HYPERVENTILATION1
HYPERTENSIVE HEART DISEASE1
HYPERNATRAEMIA1
HYPERHIDROSIS1
HYPERAMMONAEMIA1
HOMICIDAL IDEATION1
HEPATOTOXICITY1
HEPATITIS FULMINANT1
HEPATIC NECROSIS1
HALLUCINATION, VISUAL1
HAEMORRHAGE1
HAEMOPTYSIS1
HAEMOGLOBIN DECREASED1
HAEMATURIA1
GLUCOSE URINE PRESENT1
GENERALISED OEDEMA1
GASTROINTESTINAL CARCINOMA1
GALLBLADDER DISORDER1
DYSPNOEA1
Dysphagia1
DYSARTHRIA1
DISTURBANCE IN ATTENTION1
DISORIENTATION1
DILATATION ATRIAL1
DEPRESSION1
DEPRESSED LEVEL OF CONSCIOUSNESS1
DEMENTIA1
DELIRIUM1
DEEP VEIN THROMBOSIS1
CRYING1
CONTUSION1
CONGESTIVE CARDIOMYOPATHY1
Confusional state1
COMPARTMENT SYNDROME1
Circulatory collapse1
CEREBRAL HAEMORRHAGE1
CEREBRAL ATROPHY1
CARDIOMEGALY1
CARDIAC FAILURE ACUTE1
CARDIAC FAILURE1
CARDIAC DISORDER1
CARDIAC ARREST1
BRONCHITIS ACUTE1
BLOOD UREA INCREASED1
BLOOD PRESSURE DECREASED1
BLOOD IRON INCREASED1
BLOOD GLUCOSE INCREASED1
BLOOD FIBRINOGEN DECREASED1
BLOOD CREATININE INCREASED1
BLOOD CREATINE PHOSPHOKINASE MB INCREASED1
BLOOD ALBUMIN DECREASED1
BILIRUBIN CONJUGATED INCREASED1
BILIARY CIRRHOSIS1
Bacterial pyelonephritis1
BACK PAIN1
ATRIOVENTRICULAR BLOCK COMPLETE1
ARRHYTHMIA1
AORTIC VALVE SCLEROSIS1
ANTINUCLEAR ANTIBODY POSITIVE1
ANAEMIA1
ALANINE AMINOTRANSFERASE DECREASED1
AGGRESSION1
ACUTE MYOCARDIAL INFARCTION1
ACTIVITIES OF DAILY LIVING IMPAIRED1
ACTIVATED PARTIAL THROMBOPLASTIN TIME PROLONGED1
ABDOMINAL PAIN1





Filtered ChEMBL targets:

Target UniProtKB ID Activity in nm Target Name Target gene
P02766 20.6 Transthyretin TTHY_HUMAN
P21964 1 Catechol O-methyltransferase COMT_HUMAN
Q9HC97 7440 G-protein coupled receptor 35 GPR35_HUMAN



Toxicity information:

Toxicity class: 4
Toxicity type: hepatic
LD50: 1600 mg/kg



External links:

ChEBML: CHEMBL1324
DrugBank: DB00323